The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture& environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture& environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture& environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe& plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead.Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinkingthe capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

Dr. Pallaval Veera Bramhachari is currently a Head& Senior Faculty member of the Department of Biotechnology at Krishna University, Machilipatnam, India. He has earlier served as Postdoctoral research scientist at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research (QIMR-Berghofoer Research Center),), Brisbane, Australia, and DBT Postdoctoral fellow at the Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bangalore. He completed his PhD in Microbiology from Goa University, India. His major research interests are the investigation on the applied research in microbiology and cell biology including biochemical mechanism of bacterial-biofilm formations, structure-function relationship of bacterial rhamnolipids, basic and translational cancer research. He has published more than 140 research articles in Scopus-indexed journals, authored and co-authored 6 international books and invited book chapters in prestigious peer reviewedinternational and presented 47 abstracts at various national and international conferences. He has served as editorial board and reviewer for a number of national and international journals. He is a member of numerous international scientific societies and organizations, most importantly, Indian Science Congress& Society of Biological Chemists, India. He successfully completed two major research projects.  

He was awarded Travel scholarship from QIMR-2007, Australia for attending 4th Indo-Australian Biotechnology Conference at Brisbane, Australia, Awarded with young scientist travel fellowship (2007) from the DST, Govt. of India for attending XVII Lancefield International Symposium at Porto HeliGreece-2008, He was conferred with various prestigious awards, notably, Science Education Research Board (SERB), Government of India-Young Scientist award (2011) with a research project and Nominated as Associate Fellow of Andhra Pradesh Academy of Sciences (APAS)-2016, MASTERTRAINER: Andhra Pradesh English Communications Skills Project. British Council& APSCHE 2017, Andhra Pradesh State Best Scientist award-2017, Dr.V. Ramalingaswamy Memorial award for Biomedical Sciences-2019. He also obtained two Indian patents in 2017. He has more than 13 years of teaching and research experience at the university level. 

Chapter 1_Significance of microbiome on human healthcare.- Chapter 2_Animal models for microbiome studies.- Chapter 3_Bioinformatics tools for analyzing microbiomes.- Chapter 4_Modulation of Systemic Immune Responses through genital, skin, and oral microbiota.-Chapter 5_Role of microbiome in development of immune system.- Chapter 6_Understanding the interplay between host immune-microbiome interactions.- Chapter 7_Overview on human gut microbiome and its role in immunomodulation.- Chapter 8_Cancer microbiome and immunotherapy: Understanding the complexity between microbes, immunity, and cancer.- Chapter 9_Dynamics of Respiratory Microbiome in lung dysbiosis.- Chapter 10_Microbiome Therapeutics: Emerging concepts and challenges.- Chapter 11_Intestinal Microbiome and Health.- Chapter 12_Macromolecule signalling mediating inflammation and immune system interaction.- Chapter 13_Microbiome-immune homeostasis and their involvement in cancer immunotherapy.- Chapter 14_Challenges and future prospects in the microbiome intervention in human health and disease.